Hollis D Showalter Selected Research

degrasyn

6/2015	Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.
2/2014	Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I).
1/2014	Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses.
1/2012	Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response.
12/2011	A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hollis D Showalter Research Topics

Disease

4	Obesity 07/2019 - 10/2018
4	Infections 01/2019 - 12/2011
4	Neoplasms (Cancer) 01/2019 - 02/2014
2	Coinfection 12/2022 - 12/2022
2	Tuberculosis (Tuberculoses) 12/2022 - 09/2020
2	Inflammation (Inflammations) 01/2020 - 01/2019
2	Type 2 Diabetes Mellitus (MODY) 01/2019 - 10/2018
2	Caliciviridae Infections 01/2014 - 01/2012
2	Leukemia 01/2012 - 12/2011
1	Parasitic Diseases (Parasitic Disease) 09/2020
1	Edema (Dropsy) 01/2020
1	Eye Diseases (Eye Disease) 01/2020
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019
1	Weight Loss (Weight Reduction) 11/2018
1	Insulin Resistance 10/2018
1	Amphetamine-Related Disorders (Addiction, Amphetamine) 11/2016
1	Brain Diseases (Brain Disorder) 11/2016
1	Communicable Diseases (Infectious Diseases) 01/2016
1	Human Influenza (Influenza) 09/2015
1	Multiple Myeloma 02/2014
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 02/2014
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2012
1	Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis) 01/2012
1	Vesicular Stomatitis 01/2012
1	Virus Diseases (Viral Diseases) 01/2012
1	Bacterial Infections (Bacterial Infection) 12/2011
1	Colitis 09/2011
1	Hypotension (Low Blood Pressure) 09/2011
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2011

Drug/Important Bio-Agent (IBA)

5	degrasynIBA 06/2015 - 12/2011
4	Pharmaceutical PreparationsIBA 12/2022 - 06/2015
4	amlexanox (Aphthasol)FDA Link 07/2019 - 10/2018
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2012
3	UbiquitinIBA 01/2019 - 01/2012
2	Rifampin (Rifampicin)FDA LinkGeneric 12/2022 - 12/2022
2	RifamycinsIBA 12/2022 - 12/2022
2	brequinarIBA 01/2019 - 10/2017
2	Dihydroorotate DehydrogenaseIBA 01/2019 - 10/2017
2	Phosphotransferases (Kinase)IBA 11/2018 - 10/2018
2	Antiviral Agents (Antivirals)IBA 01/2016 - 01/2012
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2022
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 12/2022
1	Bacterial RNAIBA 12/2022
1	OPC-67683IBA 09/2020
1	pretomanidIBA 09/2020
1	NitroimidazolesIBA 09/2020
1	PKC-3 proteinIBA 01/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	CytokinesIBA 01/2020
1	PyrimidinesIBA 01/2020
1	LigandsIBA 01/2019
1	pyrimidineIBA 01/2019
1	teriflunomideIBA 01/2019
1	Leflunomide (Arava)FDA LinkGeneric 01/2019
1	DeuteriumIBA 01/2019
1	NucleotidesIBA 01/2019
1	ProteomeIBA 01/2019
1	Insulin (Novolin)FDA Link 11/2018
1	benzocycloheptapyridineIBA 11/2018
1	Carboxylic AcidsIBA 11/2018
1	Biological ProductsIBA 11/2018
1	NF-kappaB-Inducing KinaseIBA 11/2018
1	Interleukin-6 (Interleukin 6)IBA 11/2018
1	Protein Kinase CIBA 11/2016
1	Selective Estrogen Receptor Modulators (SERM)IBA 11/2016
1	Tamoxifen FDA LinkGeneric 11/2016
1	ProdrugsIBA 09/2015
1	Neuraminidase (Sialidase)IBA 09/2015
1	Oseltamivir (Tamiflu)FDA Link 09/2015
1	EnzymesIBA 09/2015
1	EstersIBA 09/2015
1	Deubiquitinating EnzymesIBA 06/2015
1	LipidsIBA 03/2012
1	Small Interfering RNA (siRNA)IBA 01/2012
1	alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamideIBA 12/2011
1	Tyrosine Kinase InhibitorsIBA 12/2011
1	Dextrans (Dextran)FDA Link 09/2011
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 09/2011
1	Angiotensin IIIBA 09/2011

Therapy/Procedure

5	Therapeutics 01/2020 - 01/2012
1	Drug Therapy (Chemotherapy) 01/2019